Different Approaches for Nanovaccine Formulation and Characterization

Now a day, millions of people suffer from chronic Hepatitis B Virus globally. Presently, no well-established treatment is available for the chronic Hepatitis B virus infection; the available treatment is based on host mediated immunological control and reduction of HBV-DNA levels in blood serum. There is a constant demand for new and improved vaccines, scientist have continually developed a new vaccine technology. In this research article given a different approach for the preparation of Hepatitis B vaccine, utilizing a novel drug delivery system. In this regard developed a Hepatitis B antigen loaded polymeric and lipid particles. Prepared particles were further characterized for their particles size, entrapment efficiency, morphology and in vitro release. Further, compare the formulation on the basis of characterization. Results indicated that, polymeric particles showed high entrapment efficiency, and better release. This formulation is suitable for further clinical study.