Nephroprotective activity of dichloromethane extract of leaves of Alstonia scholaris Linn. in Gentamycin induced Nephrotoxicity in rats: Preventive study
[...]with this background we decided to explore the nephroprotective role of Pimpinella anisum in a murine model of gentamicin-induced renal damage. First the powdered drug was defatted with petroleum ether (60°C-80°C); Defatted drug was then dried and again filled in soxhlet apparatus for extractio...
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| Veröffentlicht in: | Research journal of pharmacy and technology 2021-02, Vol.14 (2), p.1055-1058 |
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| container_title | Research journal of pharmacy and technology |
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| creator | Bharati, Dileep Goyal, Swapnil Bose, Anirbandeep |
| description | [...]with this background we decided to explore the nephroprotective role of Pimpinella anisum in a murine model of gentamicin-induced renal damage. First the powdered drug was defatted with petroleum ether (60°C-80°C); Defatted drug was then dried and again filled in soxhlet apparatus for extraction with dichloromethane as solvent. Gentamycin is an amino glycoside antibiotic with a wide spectrum of activities against Gram-positive and Gramnegative bacterial infections, with high preference for latter and cisplatin equally associate with nephrotoxicity as it is side effect [17,18]. [...]Gentamycin induced nephrotoxicity is well established experimental model of drug induced renal injury [19]. Creatinine derives from endogenous sources by tissue creatinine breakdown. [...]serum urea concentration is often considered a more reliable renal function prediction than serum creatinine. |
| doi_str_mv | 10.5958/0974-360X.2021.00189.X |
| format | Article |
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| ispartof | Research journal of pharmacy and technology, 2021-02, Vol.14 (2), p.1055-1058 |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Creatinine Drug dosages Flavonoids Oral administration Oxidative stress Pharmacy Proteins Uric acid Urine Variance analysis |
| title | Nephroprotective activity of dichloromethane extract of leaves of Alstonia scholaris Linn. in Gentamycin induced Nephrotoxicity in rats: Preventive study |
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