Nephroprotective activity of dichloromethane extract of leaves of Alstonia scholaris Linn. in Gentamycin induced Nephrotoxicity in rats: Preventive study

[...]with this background we decided to explore the nephroprotective role of Pimpinella anisum in a murine model of gentamicin-induced renal damage. First the powdered drug was defatted with petroleum ether (60°C-80°C); Defatted drug was then dried and again filled in soxhlet apparatus for extraction with dichloromethane as solvent. Gentamycin is an amino glycoside antibiotic with a wide spectrum of activities against Gram-positive and Gramnegative bacterial infections, with high preference for latter and cisplatin equally associate with nephrotoxicity as it is side effect [17,18]. [...]Gentamycin induced nephrotoxicity is well established experimental model of drug induced renal injury [19]. Creatinine derives from endogenous sources by tissue creatinine breakdown. [...]serum urea concentration is often considered a more reliable renal function prediction than serum creatinine.