Chemopreventive potential of adrenergic blocker in behavioral stress accelerated prostate cancer development in rats

Stimulation of a receptor leads to the activation of Ca++ permeable no selective cationic channels and transient receptor potential (TRP) channel family, which are responsible for cell proliferation, which leads to prostate cancer progression. Certain adrenergic blockers can exert anticancer activity by blocking a and ß adrenergic pathway. [...]current study examined association between prostate cancer progression and behavioural study. Clinical and epidemiological studies have identified that stress, chronic depression and lack of social support are considered as risk factors for cancer progression.1-2 Psycho emotional stress activates hypothalamicpituitary-adrenal axis (HPA) and sympathetic nervous system (SNS) that leads to release of glucocorticoids from adrenal gland, adrenaline and nor-adrenaline from adrenal medulla and sympathetic neurons.3-4 According to Reiche E. 2004hypothalamus secretes corticotrophin - releasing factor (CRF) and arginine vasopressin, which activate the HPA axis, leading to release of adrenocorticotrophic hormone, enkephalins, and endorphins. Activation of the sympathetic nervous system also stimulates the release of CRF by hypothalamic parventricular nuclei. [...]activation of one component of the system stimulates the other component.5 ß adrenergic pathway:6 SNS activation regulates cancer-related molecular pathways by direct regulation of ß-receptor bearing tumour cells and regulation of other ß-receptor bearing cells present in the tumour microenvironment, such as macrophages and vascular cells.ß2 receptor are present on prostate gland cell.