Formulation and evaluation of lignocaine hydrochloride topical gel

Developed Formulations of Physicochemical parameters such as percentage yield, drug content, pH, Viscosity, Spreadability, Extrudability and In-vitro Diffusion study were carried out for developed batches of Lignocaine Hydrochloride. The resultant lidocaine cations are then able to do reversibly restricting the sodium channels from within, keeping them secured an open express that forestalls nerve depolarization. [...]with adequate blockage, the layer of the postsynaptic neuron will at last not depolarize and will in this way neglect to transmit an activity potential. Methods: Preparation of Gel: * Accurately weighed Carbopol 934 was taken in a beaker and dispersed in 50ml distilled water. * Kept the beaker aside to swell the Carbopol for half an hour and then stirring was done. * 5ml of propylene glycol was taken in another beaker and added weighed quantity of propyl paraben and methyl paraben and stirred properly. * After all, Carbopol was dispersed, 2gm of lignocaine hydrochloride and preservatives solutions were added with constant stirring. * Finally, Distilled water was added to make up the volume up to 100ml and triethanolamine was added drop wise in the formulation5.