Hydrotropic solubilization and linearity profile of apixaban

Hydrotropic solubilization method development is the most convenient tool to enhance the aqueous solubility of such molecules to avoid harmful organic solvents like dimethyl sulphoxide, chloroform, carbon tetra chloride, methanol and ethanol etc.2 In this present study, an effort is made to improve the aqueous solubility of the selected drug Apixaban by using Sodium Salicylate as the solubilizing agent, as there is no reported method is available so far to enhance water solubility and establish linearity of selected drug molecule by Hydrotropic Solubilization method. In the condition where the test chemical fails to dissolve, try to increase the volume of solubilizing agent so as to decrease the drug concentration by a factor of 10, and then the array of mechanical trials are repeatedly made in an effort to increase the solubility of the chemical at still lower concentrations. The present newly developed method offers an accurate, reproducible, linear, economical, time saving method with a suitable concentration range for the determination of Apixaban using an environment friendly method which avoids the use of harmful and toxic solvents which are health hazardous.