Bioactivity, analytical techniques and formulative approaches for Embelin

Constituents of Embelia ribes EMB (C17H26O4, molecular weight: 294.29g/mol; orange-yellow solid of melting point 142.5°C) is virtually insoluble in water (log P 4.34) but soluble in polar organic solvents such as DMSO and diethylether [14]. EMB enhances therapeutic efficacy by radiation therapy in human prostate cancer PC-3 both in vitro and in vivo. EMB combined with X-ray radiation, has shown to increase the tumor growth inhibition and apoptosis, which is accompanied by the EMB-induced cell cycle arrest in S-phase[21]. Significant reduction in the serum blood glucose level and improvement in the body mass was observed in EMB treated, alloxan induced diabetic rats.