Effectiveness of oral nano-particle based Vitamin D solution in Pain Management: A prospective cross-sectional study

The aim of the present study was to evaluate the effectiveness of oral nano formulation of vitamin-D in pain management of some neurospinal and musculoskeletal disorders. Vitamin D is a hormone and essential nutrient for bone metabolism and neuromuscular function[1], stimulates osteoblast activity, increases intestinal absorption of calcium from diet, regulates phosphorus levels and it also potentially influences the pain pathways that are associated with changes in cortical, immunological, hormonal, and neuronal levels. Vitamin D deficiency has been reported in populations with several different types of chronic musculoskeletal pain such as osteoarthritis, rheumatoid arthritis, osteoporosis, soft tissue rheumatism, low back pain, and arthralgia[4-7]. According to Vitamin-D council, the vitamin-D status was categorised as below: