Hydrogel based nanosponges drug delivery for topical applications-A updated review

The size range is below 1pm and highly porous with a three-dimensional network and nanometric cavity. Because of porous nature and small size they can bind poorly-soluble drugs and improve their bioavailability. Advantages of nanosponges[6,7] * It provide extended release condition * Protected from degradation of drug * It is non-mutagenic, non-irritating, non-toxic and no side effects * At the pH from 1 to 11 the formulations are stable * The formulations are cost effective * Dosing frequency can be reduced * Better patient compliance. * Act as a absorbent and remove toxic and venom substance from the body Disadvantages of nanosponges[2,8] * Large molecules cannot encapsulated into nanosponges * Dose dumping * May retard the release * Depend only upon loading capacity Applications of nanosponges: In the both cases they got the result that delivery of drug through the nanosponges increased the death of cancer cells and delayed tumor growth. 2) Delivery of protein[10]: Bovine serum albumin (BSA) was used as a model protein to study the encapsulating capacity of ßcyclodextrin-based nanosponges. [...]the demand for new solid chains, proper for this family of enzymes is continuously growing.