Myelodysplastic syndrome with t(6;9)(p22;q34.1)/DEK-NUP214 better classified as acute myeloid leukemia? A multicenter study of 107 cases

t(6;9)(p22;q34.1)/DEK-NUP214 is a recurrent genetic abnormality that occurs in 1–2% of patients with acute myeloid leukemia (AML), and rarely in myelodysplastic syndrome (MDS). It has been suggested by others that all myeloid neoplasms with t(6;9)/DEK-NUP214 may be considered as AML, even when blast...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Modern pathology 2021-06, Vol.34 (6), p.1143-1152
Hauptverfasser:	Fang, Hong, Yabe, Mariko, Zhang, Xiaohui, Kim, Young, Wu, Xiaojun, Wei, Peng, Chi, Sunyi, Zheng, Lan, Garcia-Manero, Guillermo, Shao, Lina, Yuan, Ji, Shen, Yulei, Zheng, Gang, Tang, Guiling, Wang, Wei, Loghavi, Sanam, Shen, Qi, Yuan, Yongzhong, He, Rong, Chen, Dong, Medeiros, L. Jeffrey, Hu, Shimin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 45/23 692/308/409 692/499 96 96/47 Acute myeloid leukemia Adolescent Adult Aged Aged, 80 and over Bone marrow Child Chromosomal Proteins, Non-Histone - genetics Chromosomes, Human, Pair 6 - genetics Chromosomes, Human, Pair 9 - genetics Female Hematopoietic stem cells Humans Laboratory Medicine Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Male Medical prognosis Medicine Medicine & Public Health Middle Aged Myelodysplastic syndrome Myelodysplastic syndromes Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - pathology Myeloid leukemia Nuclear Pore Complex Proteins - genetics Oncogene Fusion Oncogene Proteins - genetics Oncogene Proteins, Fusion Pathology Peripheral blood Poly-ADP-Ribose Binding Proteins - genetics Stem cell transplantation Stem cells Translocation, Genetic Tumors Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	t(6;9)(p22;q34.1)/DEK-NUP214 is a recurrent genetic abnormality that occurs in 1–2% of patients with acute myeloid leukemia (AML), and rarely in myelodysplastic syndrome (MDS). It has been suggested by others that all myeloid neoplasms with t(6;9)/DEK-NUP214 may be considered as AML, even when blast count is
ISSN:	0893-3952 1530-0285
DOI:	10.1038/s41379-021-00741-w