Critical Parameters for Green Glycoluril Synthesis

We have studied the critical parameters of Micheletti’s glycoluril synthesis starting from urea and glyoxal on a statistical and multivariate analysis basis [ 12 ]. The process is potentially highly useful for scaling-up glycoluril production, and needs to be optimized. We have come to a conclusion that H 3 PO 4 could be used as well as P 4 O 10 giving high yields at temperature around 95°C, using glyoxal without prior purification. All reactions have been completed in less than 25 min with the yield as high as 80% under the optimized conditions.