Analysis of 28 hair samples from users of the hallucinogenic beverage ayahuasca

Analysis of 28 hair samples from users of the hallucinogenic beverage ayahuasca

Ayahuasca is a psychoactive beverage widely used in religious ceremonies in Amazonia. Dimethyltryptamine is the main active compound of ayahuasca. Dimethyltryptamine has many hazardous effects, including hallucinations. In the present study, a fast and reliable UPLC-MS/MS method was developed and va...

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Veröffentlicht in:Forensic science international 2021-06, Vol.323, p.110790, Article 110790
Hauptverfasser: Liu, Mengxi, Yang, Huan, Hu, Jing, Shen, Baohua, Xiang, Ping, Qiang, Huosheng, Deng, Hongxiao, Yu, Zhiguo, Shi, Yan
Format: Artikel
Sprache:eng
Schlagworte:
Accuracy
Ayahuasca
Calibration
Centrifugation
Chromatography
Criminal investigations
Dilution
Dimethyltryptamine
Drugs
Forensic science
Forensic sciences
Hair
Hair analysis
Hallucinations
LC-MS/MS
Mass spectrometry
Psychotropic drugs
Quantitation
Scientific imaging
Urine
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Zusammenfassung:Ayahuasca is a psychoactive beverage widely used in religious ceremonies in Amazonia. Dimethyltryptamine is the main active compound of ayahuasca. Dimethyltryptamine has many hazardous effects, including hallucinations. In the present study, a fast and reliable UPLC-MS/MS method was developed and validated for the quantitation of dimethyltryptamine in hair samples. Twenty-milligram hair samples were pulverized with methanol below 4 °C. After ultrasonication, centrifugation and filtration, 200 μL of supernatant was placed into an autosampler vial for LC-MS/MS analysis. The lower limit of quantitation (LLOQ) was 3 pg/mg. The resulting calibration curve for dimethyltryptamine fit the expression y = 281.50213x + 0.00231 (R2 = 0.992). Acceptable intraday and interday precision (RSD 
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2021.110790