Colorimetric determination of D-penicillamine based on the peroxidase mimetic activity of hierarchical hollow MoS2 nanotubes
[Display omitted] •Preparing a novel colorimetric sensor for D-penicillamine based on its antioxidant activity.•Utilizing hierarchical hollow MoS2 nanotubes as efficient artificial nanozymes.•Introducing N,N-diethyl-p-phenylenediamine as a suitable chromogenic substrate.•Applicability of the strateg...
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Veröffentlicht in: | Sensors and actuators. B, Chemical Chemical, 2021-04, Vol.332, p.129459, Article 129459 |
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Sprache: | eng |
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•Preparing a novel colorimetric sensor for D-penicillamine based on its antioxidant activity.•Utilizing hierarchical hollow MoS2 nanotubes as efficient artificial nanozymes.•Introducing N,N-diethyl-p-phenylenediamine as a suitable chromogenic substrate.•Applicability of the strategy for polar components containing thiol functional group.
A colorimetric assay was designed for the detection of D-penicillamine (D-PA). In this work, hierarchical hollow molybdenum disulfide nanotubes (HH-MoS2) were implemented as peroxidase mimetic catalysts. The pink-colored free cation radicals were generated through oxidation of N,N-diethyl-p-phenylenediamine (DPD) by hydrogen peroxide under the catalytic activity of HH-MoS2. The main role of HH-MoS2 was the enhancement of cation radical generation, thereby, improving the sensitivity of the sensor. In the presence of D-PA, the oxidation reaction of DPD was inhibited and the absorption bands of the cation radicals (at 510 and 551 nm) diminished while a new absorption band appeared at 475 nm. Good linearity between the absorbance ratio (A551/A475) and D-PA concentration in the range of 7.0-60.0 μg mL−1 was acquired and a detection limit of 0.63 μg mL−1 was achieved. As a practical application, this colorimetric sensor was successfully used to determine the D-PA content of the pharmaceutical formulation. |
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ISSN: | 0925-4005 1873-3077 |
DOI: | 10.1016/j.snb.2021.129459 |