Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined

In this trial, adults with obesity without diabetes were randomly assigned, after an 8-week low-calorie diet, to 1 year of placebo, an exercise program, liraglutide, or exercise plus liraglutide. Combined treatment with exercise and liraglutide improved healthy weight loss maintenance more than eith...

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Veröffentlicht in:	The New England journal of medicine 2021-05, Vol.384 (18), p.1719-1730
Hauptverfasser:	Lundgren, Julie R, Janus, Charlotte, Jensen, Simon B.K, Juhl, Christian R, Olsen, Lisa M, Christensen, Rasmus M, Svane, Maria S, Bandholm, Thomas, Bojsen-Møller, Kirstine N, Blond, Martin B, Jensen, Jens-Erik B, Stallknecht, Bente M, Holst, Jens J, Madsbad, Sten, Torekov, Signe S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue Adult Anti-Obesity Agents - adverse effects Anti-Obesity Agents - therapeutic use Antidiabetics Body fat Body Size Body weight Body weight loss Caloric Restriction Calories Cardiorespiratory fitness Combined Modality Therapy Design Diabetes mellitus Exercise Exercise Therapy Female Heart rate Hemoglobin Humans Hypocaloric diet Insulin Insulin resistance Liraglutide - adverse effects Liraglutide - therapeutic use Male Middle Aged Nutrient deficiency Obesity Obesity - diet therapy Obesity - drug therapy Obesity - therapy Physical fitness Physical training Placebos Statistical analysis Weight control Weight Loss - drug effects
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Zusammenfassung:	In this trial, adults with obesity without diabetes were randomly assigned, after an 8-week low-calorie diet, to 1 year of placebo, an exercise program, liraglutide, or exercise plus liraglutide. Combined treatment with exercise and liraglutide improved healthy weight loss maintenance more than either treatment alone.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2028198