Recent Progress in Structure-Activity Relationship Studies on Antitumor Macrolide Aplyronine A by Using Hybridization of Actin-depolymerizing Natural Product

Recent Progress in Structure-Activity Relationship Studies on Antitumor Macrolide Aplyronine A by Using Hybridization of Actin-depolymerizing Natural Product

Aplyronine A, an antitumor marine macrolide, has a novel mode of action, inducing the protein-protein interaction between two major cytoskeletons, actin and tubulin. This review discusses recent progress in the design of artificial analogs including hybridization and structure-activity relationship...

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Veröffentlicht in:Chemistry letters 2021, Vol.50 (4), p.580-584
Hauptverfasser: Ohyoshi, Takayuki, Kigoshi, Hideo
Format: Artikel
Sprache:eng
Schlagworte:
Analogs
Antibiotics
Anticancer properties
Depolymerization
Hybridization
Natural products
Proteins
Vol. 50 Commemorative Highlight Review: Molecular Chemistry
Online-Zugang:Volltext
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Zusammenfassung:Aplyronine A, an antitumor marine macrolide, has a novel mode of action, inducing the protein-protein interaction between two major cytoskeletons, actin and tubulin. This review discusses recent progress in the design of artificial analogs including hybridization and structure-activity relationship studies of aplyronine A.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.200866