A Method to Prepare Hollow Spherical Hydroxyapatite Granules for Drug Delivery

A suitable microenvironment provided by artificial granule scaffold plays a critical regulatory role in bone repairing progression. Till now, it is still a challenge to prepare large hydroxyapatite granules (millimetre level) which provide beneficial physical and chemical stimulation for bone reconstruction. Herein, we developed a facile synthetic strategy for synthesizing hydroxyapatite granules by a repaid gelling method. Also, the satisfying drug-releasing behavior of these granules further proves their potential prospect for bone tissue engineering as bone filler.