Associations between dietary-choline intake, B-vitamins and anxiety levels

[...]nutrients include choline and B-vitamins which are essential nutrients that act as co-enzymes in numerous enzymatic biological pathways and contribute to one carbon-metabolism(1). Research suggests that low-intakes of B-vitamins/choline/betaine may result in reduced synthesis of S-adenosylmethionine (SAM) for deoxyribonucleic acid methylation and acetylcholine synthesis. Large randomised controlled trials and association studies will increase statistical/study power, facilitating data essential for dietary-intake recommendations for choline and B-vitamins.