Ethanol: Unlocking an Abundant Renewable C2‐Feedstock for Catalytic Enantioselective C−C Coupling
With annual production at >85 million tons/year, ethanol is the world's largest‐volume renewable small molecule carbon source, yet its use as a C2‐feedstock in enantioselective C−C coupling is unknown. Here, the first catalytic enantioselective C−C couplings of ethanol are demonstrated in re...
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Veröffentlicht in: | Angewandte Chemie 2021-05, Vol.133 (19), p.10636-10640 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | With annual production at >85 million tons/year, ethanol is the world's largest‐volume renewable small molecule carbon source, yet its use as a C2‐feedstock in enantioselective C−C coupling is unknown. Here, the first catalytic enantioselective C−C couplings of ethanol are demonstrated in reactions with structurally complex, nitrogen‐rich allylic acetates incorporating the top 10 N‐heterocycles found in FDA‐approved drugs.
Maize to medicine! With annual production at >85 million tons/year, ethanol is the world's largest‐volume renewable small molecule carbon source, yet its use as a C2‐feedstock in enantioselective C−C coupling is unknown. The first catalytic enantioselective C−C couplings of ethanol are demonstrated in reactions with structurally complex, nitrogen‐rich allylic acetates incorporating the top 10 N‐heterocycles found in FDA‐approved drugs. |
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ISSN: | 0044-8249 1521-3757 |
DOI: | 10.1002/ange.202102694 |