Pig‐a gene mutations in bone marrow granulocytes of procarbazine‐treated F344 rats

It was previously demonstrated that procarbazine (PCZ) is positive in the rat erythrocyte Pig‐a gene mutation assay. However, since mammalian erythrocytes lack genomic DNA, it was necessary to analyze nucleated bone‐marrow erythroid precursor cells to confirm that PCZ induces mutations in the Pig‐a...

Ausführliche Beschreibung