Flash Chemistry Makes Impossible Organolithium Chemistry Possible

Organolithium reagents are often too unstable to use due to being highly reactive. This limits their application in organic synthesis. This review highlights our approach to various synthetic reactions mediated by organolithium reagents based on flash chemistry conducted in flow reactors, especially...

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Veröffentlicht in:	Chemistry letters 2021-03, Vol.50 (3), p.485-492
Hauptverfasser:	Nagaki, Aiichiro, Ashikari, Yosuke, Takumi, Masahiro, Tamaki, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Reactors Reagents Vol. 50 Commemorative Highlight Review: Molecular Chemistry
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Organolithium reagents are often too unstable to use due to being highly reactive. This limits their application in organic synthesis. This review highlights our approach to various synthetic reactions mediated by organolithium reagents based on flash chemistry conducted in flow reactors, especially utilizing space-integration of the flow reactions.
ISSN:	0366-7022 1348-0715
DOI:	10.1246/cl.200837