Synthesis of new potentially biologically active pyranopyridones with tryptamine fragment

New pyranopyridonotryptamines 3 were synthesized by a three-component reaction of pyridonotryptamines 1 , aromatic aldehydes 2 , and malononitrile. The structures of compounds 3 were confirmed by X-ray crystallography. A series of compounds 3 underwent primary screening for the effect on the course of mitosis in seeds of plants of the species Allium cepa L .