Synthesis and study of new 2H-pyranoquinolin-2-one-based inhibitors of blood coagulation factors Xa and XIa

Synthesis and study of new 2H-pyranoquinolin-2-one-based inhibitors of blood coagulation factors Xa and XIa

Condensation of 7-hydroxy-1,2,2,4-tetramethylhydroquinoline-6-carbaldehydes with various hetaryl-substituted 3-oxo esters afforded a series of hybrid hydro-6,8,8,9-tetramethyl-2 H -pyrano[3,2- g ]quinolin-2-ones. A number of these compounds exhibited relatively high inhibitory activity against blood...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Russian chemical bulletin 2021-03, Vol.70 (3), p.492-497
Hauptverfasser: Potapov, A. Yu, Paponov, B. V., Podoplelova, N. A., Panteleev, M. A., Polikarchuk, V. A., Ledenyova, I. V., Stolpovskaya, N. V., Kryl’skii, D. V., Shikhaliev, Kh. S.
Format: Artikel
Sprache:eng
Schlagworte:
Blood coagulation
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Esters
Full Articles
Inorganic Chemistry
Organic Chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Condensation of 7-hydroxy-1,2,2,4-tetramethylhydroquinoline-6-carbaldehydes with various hetaryl-substituted 3-oxo esters afforded a series of hybrid hydro-6,8,8,9-tetramethyl-2 H -pyrano[3,2- g ]quinolin-2-ones. A number of these compounds exhibited relatively high inhibitory activity against blood coagulation factors Xa and XIa.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-021-3114-6