“Metal-free” synthesis and antifungal activity of 3-thiocyanatopyrazolo[1,5-a]pyrimidines
A convenient stepwise synthesis of substituted 3-thiocyanatopyrazolo[1,5- a ]pyrimidines under mild conditions using available reagents and solvents was proposed. A number of these compounds were found to possess pronounced and selective antifungal activity, which is comparable or superior to the ac...
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| Veröffentlicht in: | Russian chemical bulletin 2021-03, Vol.70 (3), p.600-604 |
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| container_title | Russian chemical bulletin |
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| creator | Kokorekin, V. A. Khodonov, V. M. Neverov, S. V. Grammatikova, N. É. Petrosyan, V. A. |
| description | A convenient stepwise synthesis of substituted 3-thiocyanatopyrazolo[1,5-
a
]pyrimidines under mild conditions using available reagents and solvents was proposed. A number of these compounds were found to possess pronounced and selective antifungal activity, which is comparable or superior to the activity of the antifungal drugs amphotericin B and fluconazole. |
| doi_str_mv | 10.1007/s11172-021-3131-5 |
| format | Article |
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| language | eng |
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| subjects | Brief Communications Chemistry Chemistry and Materials Science Chemistry/Food Science Fungicides Inorganic Chemistry Organic Chemistry Pyrimidines Reagents Synthesis |
| title | “Metal-free” synthesis and antifungal activity of 3-thiocyanatopyrazolo[1,5-a]pyrimidines |
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