Hematological and Hepatic Effects of Ulexite in Zebrafish

[Display omitted] •Low doses of UX did not cause any oxidative stress.•Low doses of UX promoted all enzyme activities in liver of zebrafish.•UX exhibits beneficial roles on blood and liver tissues of zebrafish at lower doses.•This applications did not alter the MN rates in zebrafish erythrocytes. Th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Environmental toxicology and pharmacology 2020-11, Vol.80, p.103496, Article 103496
Hauptverfasser: Alak, Gonca, Özgeriş, Fatma Betül, Yeltekin, Aslı Çilingir, Parlak, Veysel, Ucar, Arzu, Caglar, Ozge, Turkez, Hasan, Atamanalp, Muhammed
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:[Display omitted] •Low doses of UX did not cause any oxidative stress.•Low doses of UX promoted all enzyme activities in liver of zebrafish.•UX exhibits beneficial roles on blood and liver tissues of zebrafish at lower doses.•This applications did not alter the MN rates in zebrafish erythrocytes. The ulexite (UX), a borate mineral, is used as boron source and commonly used in various industrial processes. The hematological and hepatic effects of UX were investigated by exposing adult zebrafish to UX (5, 10, 20 and 40 mg/L) over 96 hours. The blood and liver tissues were taken at the end of the trial period then micronucleus (MN) rates, oxidative DNA damage (8-OHdG), apoptosis (Caspase-3), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), myeloperoxidase (MPO), paraoxonase (PON), arylesterase (AR) and lipid peroxidation (MDA) levels were determined. Genotoxic damage by UX occurred only at 40 mg/L in the blood MN assay. Oxidative stress, oxidative DNA damage and apoptosis in liver also occurred at this dose. Moreover, 5-20 mg/L doses led to decreases of DNA damage and apoptosis levels via promoting antioxidant system in liver tissues. UX exhibits beneficial roles on blood and liver tissues of zebrafish at relatively lower doses, which may be relevant to nutritional and medicinal industries.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2020.103496