Structural and antioxidant properties of guanylhydrazinium pyrazine-2-carboxylate

In general, molecules with certain functional groups such as amine (-NH 2 ) and carboxyl (-COOH) can promote the growth of co-crystals leading to the formation of supramolecular networks. However, if the differences in the pKa values of the two molecules are large [pKa (base)—pKa (acid)], salts can...

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Veröffentlicht in:Journal of materials science. Materials in electronics 2021-03, Vol.32 (6), p.7704-7718
Hauptverfasser: Packiaraj, S., Kousalya, L., Pushpaveni, A., Poornima, S., Puschmann, H., Govindarajan, S.
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Sprache:eng
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Zusammenfassung:In general, molecules with certain functional groups such as amine (-NH 2 ) and carboxyl (-COOH) can promote the growth of co-crystals leading to the formation of supramolecular networks. However, if the differences in the pKa values of the two molecules are large [pKa (base)—pKa (acid)], salts can result instead of ‘real’ co-crystals. Here, we report the formation of such salt by letting pyrazine-2-carboxylic acid (pKa = 2.9) crystallize together with aminoguanidine (pKa = 11.5; high Δpka = 8.6) a nitrogen-rich organic base. The title salt has been prepared by slow evaporation of an equimolar ratio of guanylhydrazine bicarbonate (i.e., aminoguanidine bicarbonate (AgunH.HCO 3 )) and pyrazine-2-carboxylic acid (Pymca) in aqueous medium. The salt was characterized by IR spectroscopy, powder and single-crystal X-ray diffraction techniques. This material shows enhanced antioxidant activity and this is due to the crucial role of hydrazinic moiety in the aminoguanidinium salt.
ISSN:0957-4522
1573-482X
DOI:10.1007/s10854-021-05489-2