The Effect of Lycopene on DNA Damage and Repair in Fluoride-Treated NRK-52E Cell Line
Exposure of fluorine at toxic concentrations causes serious damage by accumulating in especially bones, kidneys, and other soft tissues. Fluorine at cytotoxic concentrations may cause DNA damage. This study aims to determine the level of DNA damage due to sodium fluoride (NaF) at different hours (3r...
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Veröffentlicht in: | Biological trace element research 2021-05, Vol.199 (5), p.1979-1985 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Exposure of fluorine at toxic concentrations causes serious damage by accumulating in especially bones, kidneys, and other soft tissues. Fluorine at cytotoxic concentrations may cause DNA damage. This study aims to determine the level of DNA damage due to sodium fluoride (NaF) at different hours (3rd, 12th, and 24th hours) and in IC
50
concentrations designated for each hour and reveal the protective effect of lycopene on possible damage. The best enhancer concentrations (1 μM) of microtitration (MTT) viability test and proliferation of lycopene and IC
50
values of NaF at the 3rd, 12th, and 24th hour were 9600, 5500, and 3200 μM, respectively. DNA damage significantly increased in all NaF-treated groups in comparison with the control group (
p
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ISSN: | 0163-4984 1559-0720 |
DOI: | 10.1007/s12011-020-02288-4 |