Methods of investigation and improvement of the quality of life in oro-maxillo-facial malignancy- a systematic review

Objective: Cancer is a complex entity that requires a multidisciplinary approach from a team of specialists to help the patient from various perspectives. Morphological and functional impairments may be present from the beginning of the malignant process, may gradually increase or become more intense during the treatment period. Through the intervention of radioprotective agents at the molecular level it is possible to reduce the negative consequences given by the multimodal approach. The aim of the paper is to detect the radioprotective effect of amifostine administered during cancer therapy as a method of improving quality of life. Material and Method: In order to achieve the proposed goal, a systematic research of the specialized literature was carried out. Results: Favorable effects for chronic xerostomia were noted in five articles. Two papers concluded a positive outcome for acute xerostomia. Three articles did not show encouraging results on this acute symptom. Some authors have suggested that amifostine has a protective effect for other symptoms. The studies presented heterogeneous conclusions regarding the protective effect of amifostine on the tissues of the oro-maxillo-facial territory. Through the use of such methods as the administration of amifostine, patients are made aware of the possibility of improving their long-term lives. Conclusion: The cytoprotective role of amifostine is demonstrated by its selectivity to unmodified tissues. The benefits can be quantified in the long run and can facilitate the patient's recovery after cancer therapy, improving the quality of life.