0310 INSOMNIA SYMPTOMS AGGRAVATES METABOLIC SYNDROME BY INCREASING GLUCOSE LEVELS: A POPULATION-BASED STUDY

Abstract Introduction: Previous studies have suggested a relationship between metabolic syndrome (MetS) and sleep disturbances, such as obstructive sleep apnea and sleep deprivation. However, little is known about the potential interaction among MetS and insomnia. The aim of this study was to investigate the interaction effects between insomnia symptoms and MetS on sleep, metabolic and inflammatory parameters from a representative sample of an urban population. Methods: This was a cross-sectional study that included a total of 1,006 individuals who fitted research criteria, answered questionnaires and underwent physical evaluation, polysomnography and blood collection for biochemical analysis. Insomnia and MetS were defined according to validated questionnaires and the National Cholesterol Education Program III, respectively, allowing the distribution of subjects into 4 groups: control (CTRL), insomnia symptoms (INS), MetS and MetS+INS. Results: Insomnia increased the number of MetS positive criteria in the MetS+INS group, which showed an increase of 7.9% in the glucose levels compared to the MetS group. No significant changes in insulin sensitivity was found. Moreover, no interaction effects between MetS and insomnia symptoms were observed regarding sleep architecture, pro-inflammatory markers and cardiovascular parameters. Conclusion: This study suggests that insomnia symptoms may potentiate some of the alterations in glucose metabolism caused by MetS. As insomnia complaints are highly prevalent in the general population, they should be assessed in clinical practice for better management and prevention of metabolic diseases. Support (If Any): This work was supported by Associacao Fundo de Incentivo a Pesquisa (AFIP) and the São Paulo Research Foundation (grant #2014/15259-2 to CH). ST, LB, DP and MLA received CNPq Fellowships.