1061 SLEEP DURATION ASSOCIATES WITH METABOLIC AND NON-METABOLIC DISEASES CURATED FROM ELECTRONIC MEDICAL RECORDS IN THE PARTNERS BIOBANK

Abstract Introduction: Sleep duration associates with a host of metabolic and non-metabolic diseases. This investigation examines whether habitual sleep duration associates with diseases curated from electronic medical records (EMR) from the Partners Biobank. Methods: The Partners Biobank is hospital-based cohort study from the Partners HealthCare hospitals with EMR and genetic data supplemented with health surveys. Diseases were curated from EMR using structured and unstructured data and robust phenotype algorithms [obesity (n=3790), type 1 diabetes (T1D; n=85), type 2 diabetes (T2D; n=792), coronary artery disease (CAD; n=854), stroke (n=113), hypertension (n=4746), congestive heart failure (n=95), depression (n=1264), chronic obstructive pulmonary disorder (n=90), asthma (n=1182), breast cancer (n=797)]. Sleep data were ascertained from a health information survey administered at enrollment to 20,845 participants. Weighted average sleep duration was computed using self-reported weekday and weekend bed and wake-up times. Self-reported sleep durations 14 hours and self-reported shift-work were excluded. Sleep duration was categorized as