1054 SLEEP DISORDERED BREATHING IN PATIENTS SCHEDULED FOR CAROTID ENDARTERECTOMY

Abstract Introduction: Obstructive sleep apnea (OSA) seems to be an independent risk factor for carotid atherosclerosis, but there are limited data on the coexistence of OSA and hemodynamically significant carotid stenosis.The aim of this study was to determine the prevalence of OSA in patients with carotid stenosis and whether carotid plaque removal improves symptoms of OSA and sleep study parameters as was suggested in the literature.Presented data are a part of an ongoing larger study, measuring influence of OSA severity on the histological structure and presence of atherogenesis markers in the carotid artery plaque in endarterectomy specimens. Methods: Sleep study (WatchPAT) was applied preoperatively in 49 patients scheduled for endarterectomy. 11 out of 49 patients (5 males) with mean BMI of 27,2, had sleep study, Epworth Sleepiness Scale (ESS) and STOP Bang questionnaire pre- and postoperatively (with average 4,5 months follow-up). Results: Subjects were categorized into 4 groups: mild (n=13), moderate (n=13), severe (n=8) OSA and healthy patients (n=15) according to the sleep study result. Mean pre- and postoperative apnea/hypopnea index (AHI), oxygen desaturation index (ODI) and respiratory disturbance index (RDI) were 14,7(±13,7) and 21,6(±17,5); 9,5(±11,8) and 14,1(±15); 16,8(±13) and 22,5(±17,4), respectively. Mean pre- and postoperative ESS score was 6,4(±5,3) and 6,9(±4,8), respectively. According to STOP Bang questionnaire 2, 4 and 5 subjects had low, intermediate and high risk of OSA preoperatively, respectively. In 4 out of 11 subjects decrease in risk of OSA was observed postoperatively, while in the rest of the group no change was reported. Conclusion: OSA is more prevalent in patients with carotid stenosis than in general population. According to our results, there is a deterioration in sleep parameters in endarterectomy follow-up, which is opposite to previous studies. Support (If Any): no support