0338 WOMEN WITH INSOMNIA AND DEBILITATING MIGRAINES: SEQUENTIAL ADMINISTRATION OF ONLINE TREATMENT- THE WINDSOR STUDY

Abstract Introduction: Insomnia commonly co-occurs with chronic migraines (CM). Treatments for insomnia that accommodate the debilitating nature of CM remain understudied. This is a proof-of-concept study, which aims to evaluate the feasibility, acceptability and effectiveness of digital Cognitive Behavioral Therapy for Insomnia (dCBT-I) for individuals with CM and insomnia (CM-I). Methods: A multiple baseline design was employed following SCRIBE (single-case reporting guidelines in behavioral interventions). Forty-two females with CM-I were randomized to receive dCBT-I (www.sleepio.com) after 2, 4 or 6 weeks of baseline sleep assessment. Completion and acceptability rates, and changes in sleep and migraines after treatment were assessed. Daily sleep diary data across baseline and treatment periods were examined visually according to guidelines and changes in sleep temporally associated with the initiation of dCBT-I were identified. Results: Out of 39 participants who started the program, 35 (89.7%) completed dCBT-I. Of these completers, 33 (94.3%) reported being satisfied (n=16) or very satisfied (n=17) with treatment. In addition, 65.7% of completers reported a clinically meaningful difference in their sleep as indicated by a change of ≥ 8 on the Insomnia Severity Index (ISI). There was a significant change in ISI scores from baseline (mean [SD]=17.6 [4.0]) to post-treatment (mean[SD]=7.7 [4.1]), t(34)=10.8, p