Impact of Varroa destructor and associated pathologies on the colony collapse disorder affecting honey bees

Varroa mite is the major threat to the western honey bee, Apis mellifera, and the cause of significant economic losses in the apiculture industry. Varroa destructor feeds on brood and adult bees being responsible for vectoring virus infections and other diseases. This study analyses the role of Varroa and other associated pathogens, such as viruses or the fungus Nosema ceranae, and their relationships regarding the viability of the bee colony. It has been carried out during one beekeeping season, with the subspecies A. m. iberiensis, commonly used in the apiculture industry of Spain. Our study shows a significant relationship between the presence of Varroa destructor and viral infection by deformed wing virus and acute bee paralysis virus. Nosema ceranae behaved as an opportunistic pathogen. In addition, this study explored a potential naturally occurring subset of peptides, responsible for the humoral immunity of the bees. The expression of the antimicrobial peptides abaecin and melittin showed a significant relationship with the levels of Varroa mite and the deformed wing virus. [Display omitted] •Varroa's association with other pathogens determines the dead of the honey bee hives.•Deformed wings virus occurred repeatedly during inspections undertaken in the hives.•Acute bee paralysis virus and chronic bee paralysis virus were unevenly detected.•Nosema ceranae behave as an opportunistic pathogen.•A relationship between the AMPs with Varroa and the related viruses was observed.