Synthesis, Molecular Docking, In Vitro Anti-Bacterial, and Anti-Cancer Activities of Some Novel Oxo-Spiro Chromene Schiff’s Bases

A series of novel oxo-spiro chromene Schiff’s bases were synthesized by condensing 2,7-diamino-2'-oxospiro[chromene-4,3'-indoline]-3-carbonitrile, and series of aromatic aldehydes. Spectrochemical techniques have corroborated the formation of desired products. Derivatives were screened in vitro for antibacterial and anticancer activities. Molecular docking analysis was also performed to predict the possible mode of action of these derivatives. The docking analysis ascertained that these derivatives regulate the antimicrobial potential via inhibition of DNA gyrase and anticancer potential via inhibition of CDK 6. Among all the synthesized compounds, Nitro derivatives have exhibited eminent anticancer and antibacterial activities.