Post transcriptional modifications may lead to changes in newborn goats' skeletal muscle proteome as a consequence of maternal feed restriction at different stages of gestation

Costa et al discuss their study on the impact of maternal feed restriction at different stages of gestation on proteomic profile in the skeletal muscle of newborn goats. A total of 14 pregnant dams were randomly divided into one of the follow dietary treatments. Longissimus muscle was sampled from male newborn goats and submitted to sarcoplasmic protein extraction and liquid chromatography coupled to mass spectrometry (LC-MS) analysis. The results indicate that maternal feed restriction during different stages of gestation alters enzymes and protein domains abundance associated with nucleotide metabolism in the skeletal muscle of newborn goats. Moreover, the lack of correlation between protein-transcript suggests the importance of post-transcriptional regulation of skeletal muscle metabolism as a consequence of maternal feed restriction at different stages of gestation.