Laboratory bioassay, greenhouse experiment and 3D‐QSAR studies on berberine analogues: a search for new herbicides based on natural products

BACKGROUND Berberine is a herbicidal chemical that we isolated from Coptis chinensis. In continuation of our program aimed at discovering and developing natural botanical herbicides, we evaluated the herbicidal activities of 39 berberine analogues and developed a three‐dimensional quantitative struc...

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Veröffentlicht in:	Pest management science 2021-04, Vol.77 (4), p.2054-2067
Hauptverfasser:	Zhang, Xiaohong, Zhu, Tingfei, Bi, Xiaoyang, Yang, Sifan, Huang, Jiguang, Zhou, Lijuan
Format:	Artikel
Sprache:	eng
Schlagworte:	3D‐QSAR Agriculture Agronomy Berberine Berberine - pharmacology berberine analogues Bioassays Biological Assay Biological Products Chloride Chlorides Contours coptisine chloride Duckweed Electric fields Electropositivity Electrostatic properties Entomology Glyphosate Herbicides Herbicides - pharmacology Hydrogen bonds Hydrophobicity Laboratories Life Sciences & Biomedicine natural herbicide Natural products Nitrogen Quantitative Structure-Activity Relationship Science & Technology Structure-activity relationships Three dimensional models Weeds worenine chloride
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Beschreibung
Zusammenfassung:	BACKGROUND Berberine is a herbicidal chemical that we isolated from Coptis chinensis. In continuation of our program aimed at discovering and developing natural botanical herbicides, we evaluated the herbicidal activities of 39 berberine analogues and developed a three‐dimensional quantitative structure–activity relationship (3D‐QSAR) model. RESULTS Among these 39 analogs, the most active compounds were determined to be worenine chloride and coptisine chloride, with median inhibitory concentration (IC50) values on all eight tested weed species of
ISSN:	1526-498X 1526-4998
DOI:	10.1002/ps.6233