Optimizing PD-L1 evaluation on cytological samples from advanced non-small-cell lung cancer

Programmed cell death-ligand 1 (PD-L1) predicts response to immune checkpoint inhibitors in non-small-cell lung cancer (NSCLC) patients. Most NSCLCs are diagnosed at an advanced stage and using minimally invasive diagnostic procedures that yield small biopsies or cytological samples. Cytological sme...

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Veröffentlicht in:	Immunotherapy 2020-02, Vol.12 (3), p.183-193
Hauptverfasser:	Bozzetti, Cecilia, Squadrilli, Anna, Nizzoli, Rita, Lagrasta, Costanza, Gasparro, Donatello, Majori, Maria, Filippo, Massimo De, Becchi, Gabriella, Azzoni, Cinzia, Campanini, Nicoletta, Pedrazzi, Giuseppe, Zavani, Andrea, Silini, Enrico Maria, Tiseo, Marcello, Gnetti, Letizia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Apoptosis B7-H1 Antigen - genetics B7-H1 Antigen - metabolism biomarker Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biopsy Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - pathology Cell death Cellular biology Chromosomes Cytodiagnosis - methods Cytology Deoxyribonucleic acid DNA Female FISH Fluorescence in situ hybridization Gene Dosage Histology Humans Immune checkpoint inhibitors Immunocytochemistry Immunohistochemistry immunostaining In Situ Hybridization, Fluorescence L1 gene L1 protein Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - pathology Lymphatic system Male Metastasis Middle Aged Mutation Non-small cell lung carcinoma NSCLC PD-L1 PD-L1 protein Pleural effusion Reproducibility of Results Small cell lung carcinoma smears Statistical analysis Tumors Ultrasonic imaging
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Zusammenfassung:	Programmed cell death-ligand 1 (PD-L1) predicts response to immune checkpoint inhibitors in non-small-cell lung cancer (NSCLC) patients. Most NSCLCs are diagnosed at an advanced stage and using minimally invasive diagnostic procedures that yield small biopsies or cytological samples. Cytological smears and paired histological samples from 52 advanced NSCLC patients were tested for PD-L1 expression by immunocyto/histochemistry (ICC/IHC) and for gene status by FISH. was overexpressed in 9/52 (17%) cytological samples and in seven (13.5%) matched biopsies. The concordance between immunocytochemistry and IHC was 92.3% (48/52; p
ISSN:	1750-743X 1750-7448
DOI:	10.2217/imt-2019-0138