4CPS-320 Improving medication adherence and patients’ experience after heart transplant using a multilevel eHealth intervention: the mHeart clinical trial

Background and importanceMultimorbidity and therapeutic complexity are undermining health outcomes in chronic populations. Medication non-adherence may be a consequence of this complexity and is a direct cause of graft loss and death after a heart transplant (HTx). Effective interventions to improve medication adherence and lifestyle habits require a proactive interdisciplinary team and integrated care models. The development and implementation of internet based health technologies (eHealth) may lead to implementation of such chronic care programmes in clinical practice.Aim and objectivesTo improve recipients’ adherence to immunosuppressive medication (IS). Secondary objectives were to improve patients’ experience of their therapeutic regimens (TR) and to optimise clinical practice.Material and methodsAn eHealth model was implemented in a HTx hospital’s outpatient clinic. The software developed (mHeart) was a mobile and website application (https://n9.cl/ajut). The model was validated previously in a pilot study.1 For this purpose, an intensive, individually tailored, behavioural based multicomponent intervention performed using the mHeart features in an interdisciplinary environment was established. The study design is described in figure 1.Abstract 4CPS-320 Figure 1Patient allocation during the study period differed depending on the time post-transplant. Chronic-stage recipients (>1.5 years after HTx at the time of study inclusion) were included inthe parallel RCT and were randomly assigned 1:1 to the control group or intervention group. Acute-stage recipients (