The storage stability of Bacillus subtilis spore displaying cysteine protease of Clonorchis sinensis and its effect on improving the gut microbiota of mice

Bacillus subtilis ( B. subtilis ) spore can serve as an ideal vehicle for expressing heterologous antigens, and elicit specific immune responses by oral administration. In previous studies, we successfully constructed the recombinant B. subtilis spores expressing cysteine protease of Clonorchis sine...

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Veröffentlicht in:	Applied microbiology and biotechnology 2021-03, Vol.105 (6), p.2513-2526
Hauptverfasser:	Tang, Zeli, Wu, Zhanshuai, Sun, Hengchang, Zhao, Lu, Shang, Mei, Shi, Mengchen, Jiang, Hongye, Lin, Zhipeng, Zhou, Xinyi, Li, Xuerong, Yu, Xinbing, Huang, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Helminth Antigens Applied Microbial and Cell Physiology Bacillus subtilis Bacillus subtilis - genetics Bacteria Biomedical and Life Sciences Biotechnology Clonorchiasis - prevention & control Clonorchis sinensis Clonorchis sinensis - genetics Control Cysteine Cysteine Proteases Cysteine proteinase Cysteine proteinases Digestive system Gastrointestinal Microbiome Gastrointestinal tract Immune response Immunization Intestinal microflora Intestine Life Sciences Low temperature Mice Microbial Genetics and Genomics Microbiology Microbiota Microbiota (Symbiotic organisms) Microorganisms Morphology Mucosal immunity Oral administration Physiological aspects Probiotics Protease Safety Shelf life Side effects Spores Spores (Botany) Spores, Bacterial Storage Storage stability
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