An immediate or early invasive strategy in non-ST-elevation acute coronary syndrome: The OPTIMA-2 randomized controlled trial

In intermediate- and high-risk non-ST elevated acute coronary syndrome (NSTE-ACS) patients, a routine invasive approach is recommended. The timing of coronary angiography remains controversial. To assess whether an immediate (

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Bibliographische Detailangaben
Veröffentlicht in:	The American heart journal 2021-04, Vol.234, p.42-50
Hauptverfasser:	Fagel, Nick D., Amoroso, Giovanni, Vink, Maarten A., Slagboom, Ton, van der Schaaf, René J., Herrman, Jean-Paul, Patterson, Mark S., Oosterwerff, Erik F.J., Vos, Nicola S., Verheugt, Freek W.A., Tijssen, Jan G.P., de Winter, Robbert J., Riezebos, Robert K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndromes Aged Angiography Anticoagulants Area Under Curve Aspirin Aspirin - adverse effects Aspirin - therapeutic use Bleeding Cardiovascular disease Cause of Death Clinical trials Combined Modality Therapy - methods Coronary Angiography Creatine Kinase, MB Form - blood Drug dosages Early Termination of Clinical Trials Factor Xa Inhibitors - adverse effects Factor Xa Inhibitors - therapeutic use Female Fondaparinux - adverse effects Fondaparinux - therapeutic use Heart attacks Humans Male Medical Futility Medical imaging Non-ST Elevated Myocardial Infarction - diagnostic imaging Non-ST Elevated Myocardial Infarction - mortality Non-ST Elevated Myocardial Infarction - pathology Non-ST Elevated Myocardial Infarction - therapy Patients Percutaneous Coronary Intervention - methods Platelet Aggregation Inhibitors - adverse effects Platelet Aggregation Inhibitors - therapeutic use Prospective Studies Statistical analysis Strategy Ticagrelor - adverse effects Ticagrelor - therapeutic use Time Factors
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Beschreibung
Zusammenfassung:	In intermediate- and high-risk non-ST elevated acute coronary syndrome (NSTE-ACS) patients, a routine invasive approach is recommended. The timing of coronary angiography remains controversial. To assess whether an immediate (
ISSN:	0002-8703 1097-6744
DOI:	10.1016/j.ahj.2021.01.001