The Discrete Breast Cancer Stem Cell Mammosphere Activity of Group 10‐Bis(azadiphosphine) Metal Complexes
We report the anti‐breast cancer stem cell (CSC) properties of a series of Group 10‐bis(azadiphosphine) complexes 1–3 under exclusively three‐dimensional cell culture conditions. The breast CSC mammosphere potency of 1–3 is dependent on the Group 10 metal present, increasing in the following order:...
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| Veröffentlicht in: | Angewandte Chemie 2021-03, Vol.133 (12), p.6778-6783 |
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| container_title | Angewandte Chemie |
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| creator | Xiao, Zhiyin Johnson, Alice Singh, Kuldip Suntharalingam, Kogularamanan |
| description | We report the anti‐breast cancer stem cell (CSC) properties of a series of Group 10‐bis(azadiphosphine) complexes 1–3 under exclusively three‐dimensional cell culture conditions. The breast CSC mammosphere potency of 1–3 is dependent on the Group 10 metal present, increasing in the following order: 1 (nickel complex) |
| doi_str_mv | 10.1002/ange.202014242 |
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Cancer stem cells (CSCs) are associated to cancer relapse and metastasis. Herein, the breast CSC activities of Group 10‐bis(azadiphosphine) complexes under exclusively three‐dimensional cell culture conditions, are systematically compared. Breast CSC mammosphere inhibition and potency was highly dependent on the Group 10 metal present.</description><identifier>ISSN: 0044-8249</identifier><identifier>EISSN: 1521-3757</identifier><identifier>DOI: 10.1002/ange.202014242</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>antitumour agents ; Apoptosis ; Breast cancer ; cancer stem cells ; Caspase ; Cell culture ; Chemistry ; Coordination compounds ; DNA damage ; Group 10 ; mammosphere ; Metal complexes ; Nickel ; Palladium ; Platinum ; Salinomycin ; Stem cells</subject><ispartof>Angewandte Chemie, 2021-03, Vol.133 (12), p.6778-6783</ispartof><rights>2020 Wiley‐VCH GmbH</rights><rights>2021 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2022-9a3b0869a2d7a4afea40f547aacb61cb4f51ddef8826e24e17b382afef2f46a13</citedby><cites>FETCH-LOGICAL-c2022-9a3b0869a2d7a4afea40f547aacb61cb4f51ddef8826e24e17b382afef2f46a13</cites><orcidid>0000-0001-7676-2464 ; 0000-0002-1466-0953 ; 0000-0002-7047-6384</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fange.202014242$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fange.202014242$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Xiao, Zhiyin</creatorcontrib><creatorcontrib>Johnson, Alice</creatorcontrib><creatorcontrib>Singh, Kuldip</creatorcontrib><creatorcontrib>Suntharalingam, Kogularamanan</creatorcontrib><title>The Discrete Breast Cancer Stem Cell Mammosphere Activity of Group 10‐Bis(azadiphosphine) Metal Complexes</title><title>Angewandte Chemie</title><description>We report the anti‐breast cancer stem cell (CSC) properties of a series of Group 10‐bis(azadiphosphine) complexes 1–3 under exclusively three‐dimensional cell culture conditions. The breast CSC mammosphere potency of 1–3 is dependent on the Group 10 metal present, increasing in the following order: 1 (nickel complex) <2 (palladium complex) <3 (platinum complex). Notably, 3 reduces the formation and size of mammospheres to a greater extent than salinomycin, an established CSC‐active compound, or any reported anti‐CSC metal complex tested under similar conditions. Mechanistic studies suggest that the most effective complexes 2 and 3 readily penetrate CSC mammospheres, enter CSC nuclei, induce genomic DNA damage, and trigger caspase‐dependent apoptosis. To the best of our knowledge, this is the first study to systematically probe the anti‐CSC activity of a series of structurally related Group 10 complexes and to be conducted entirely using three‐dimensional CSC culture conditions.
Cancer stem cells (CSCs) are associated to cancer relapse and metastasis. Herein, the breast CSC activities of Group 10‐bis(azadiphosphine) complexes under exclusively three‐dimensional cell culture conditions, are systematically compared. Breast CSC mammosphere inhibition and potency was highly dependent on the Group 10 metal present.</description><subject>antitumour agents</subject><subject>Apoptosis</subject><subject>Breast cancer</subject><subject>cancer stem cells</subject><subject>Caspase</subject><subject>Cell culture</subject><subject>Chemistry</subject><subject>Coordination compounds</subject><subject>DNA damage</subject><subject>Group 10</subject><subject>mammosphere</subject><subject>Metal complexes</subject><subject>Nickel</subject><subject>Palladium</subject><subject>Platinum</subject><subject>Salinomycin</subject><subject>Stem cells</subject><issn>0044-8249</issn><issn>1521-3757</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkD1PwzAQQC0EEqWwMltigSHFdpyvsYRSkFoYKLN1Sc7UJWmCnQJl4ifwG_klpCqCkemW9-5Oj5BjzgacMXEOy0ccCCYYl0KKHdLjgeCeHwXRLukxJqUXC5nskwPnFoyxUERJjzzN5kgvjcsttkgvLIJraQrLHC29b7GiKZYlnUJV1a6Zo0U6zFvzYto1rTUd23rVUM6-Pj4vjDuFdyhMM9-QZolndIotlDStq6bEN3SHZE9D6fDoZ_bJw9Voll57k7vxTTqceHn3vfAS8DMWhwmIIgIJGkEyHcgIIM9CnmdSB7woUMexCFFI5FHmx6LjtNAyBO73ycl2b2Pr5xW6Vi3qlV12J1UXIEpkJH3RUYMtldvaOYtaNdZUYNeKM7UJqjZB1W_QTki2wqspcf0PrYa349Gf-w1Vj3tk</recordid><startdate>20210315</startdate><enddate>20210315</enddate><creator>Xiao, Zhiyin</creator><creator>Johnson, Alice</creator><creator>Singh, Kuldip</creator><creator>Suntharalingam, Kogularamanan</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0001-7676-2464</orcidid><orcidid>https://orcid.org/0000-0002-1466-0953</orcidid><orcidid>https://orcid.org/0000-0002-7047-6384</orcidid></search><sort><creationdate>20210315</creationdate><title>The Discrete Breast Cancer Stem Cell Mammosphere Activity of Group 10‐Bis(azadiphosphine) Metal Complexes</title><author>Xiao, Zhiyin ; Johnson, Alice ; Singh, Kuldip ; Suntharalingam, Kogularamanan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2022-9a3b0869a2d7a4afea40f547aacb61cb4f51ddef8826e24e17b382afef2f46a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>antitumour agents</topic><topic>Apoptosis</topic><topic>Breast cancer</topic><topic>cancer stem cells</topic><topic>Caspase</topic><topic>Cell culture</topic><topic>Chemistry</topic><topic>Coordination compounds</topic><topic>DNA damage</topic><topic>Group 10</topic><topic>mammosphere</topic><topic>Metal complexes</topic><topic>Nickel</topic><topic>Palladium</topic><topic>Platinum</topic><topic>Salinomycin</topic><topic>Stem cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Zhiyin</creatorcontrib><creatorcontrib>Johnson, Alice</creatorcontrib><creatorcontrib>Singh, Kuldip</creatorcontrib><creatorcontrib>Suntharalingam, Kogularamanan</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Angewandte Chemie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Zhiyin</au><au>Johnson, Alice</au><au>Singh, Kuldip</au><au>Suntharalingam, Kogularamanan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Discrete Breast Cancer Stem Cell Mammosphere Activity of Group 10‐Bis(azadiphosphine) Metal Complexes</atitle><jtitle>Angewandte Chemie</jtitle><date>2021-03-15</date><risdate>2021</risdate><volume>133</volume><issue>12</issue><spage>6778</spage><epage>6783</epage><pages>6778-6783</pages><issn>0044-8249</issn><eissn>1521-3757</eissn><abstract>We report the anti‐breast cancer stem cell (CSC) properties of a series of Group 10‐bis(azadiphosphine) complexes 1–3 under exclusively three‐dimensional cell culture conditions. The breast CSC mammosphere potency of 1–3 is dependent on the Group 10 metal present, increasing in the following order: 1 (nickel complex) <2 (palladium complex) <3 (platinum complex). Notably, 3 reduces the formation and size of mammospheres to a greater extent than salinomycin, an established CSC‐active compound, or any reported anti‐CSC metal complex tested under similar conditions. Mechanistic studies suggest that the most effective complexes 2 and 3 readily penetrate CSC mammospheres, enter CSC nuclei, induce genomic DNA damage, and trigger caspase‐dependent apoptosis. To the best of our knowledge, this is the first study to systematically probe the anti‐CSC activity of a series of structurally related Group 10 complexes and to be conducted entirely using three‐dimensional CSC culture conditions.
Cancer stem cells (CSCs) are associated to cancer relapse and metastasis. Herein, the breast CSC activities of Group 10‐bis(azadiphosphine) complexes under exclusively three‐dimensional cell culture conditions, are systematically compared. Breast CSC mammosphere inhibition and potency was highly dependent on the Group 10 metal present.</abstract><cop>Weinheim</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/ange.202014242</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-7676-2464</orcidid><orcidid>https://orcid.org/0000-0002-1466-0953</orcidid><orcidid>https://orcid.org/0000-0002-7047-6384</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | antitumour agents Apoptosis Breast cancer cancer stem cells Caspase Cell culture Chemistry Coordination compounds DNA damage Group 10 mammosphere Metal complexes Nickel Palladium Platinum Salinomycin Stem cells |
| title | The Discrete Breast Cancer Stem Cell Mammosphere Activity of Group 10‐Bis(azadiphosphine) Metal Complexes |
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