The Discrete Breast Cancer Stem Cell Mammosphere Activity of Group 10‐Bis(azadiphosphine) Metal Complexes

The Discrete Breast Cancer Stem Cell Mammosphere Activity of Group 10‐Bis(azadiphosphine) Metal Complexes

We report the anti‐breast cancer stem cell (CSC) properties of a series of Group 10‐bis(azadiphosphine) complexes 1–3 under exclusively three‐dimensional cell culture conditions. The breast CSC mammosphere potency of 1–3 is dependent on the Group 10 metal present, increasing in the following order:...

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Veröffentlicht in:Angewandte Chemie 2021-03, Vol.133 (12), p.6778-6783
Hauptverfasser: Xiao, Zhiyin, Johnson, Alice, Singh, Kuldip, Suntharalingam, Kogularamanan
Format: Artikel
Sprache:eng
Schlagworte:
antitumour agents
Apoptosis
Breast cancer
cancer stem cells
Caspase
Cell culture
Chemistry
Coordination compounds
DNA damage
Group 10
mammosphere
Metal complexes
Nickel
Palladium
Platinum
Salinomycin
Stem cells
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Zusammenfassung:We report the anti‐breast cancer stem cell (CSC) properties of a series of Group 10‐bis(azadiphosphine) complexes 1–3 under exclusively three‐dimensional cell culture conditions. The breast CSC mammosphere potency of 1–3 is dependent on the Group 10 metal present, increasing in the following order: 1 (nickel complex)
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.202014242