Transcriptional profiling of microglia in the injured brain reveals distinct molecular features underlying neurodegeneration
Neurotrauma has been recognized as a risk factor for neurodegenerative diseases, and sex difference of the incidence and outcome of neurodegenerative diseases has long been recognized. Past studies suggest that microglia could play a versatile role in both health and disease. So far, the microglial...
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| Veröffentlicht in: | Glia 2021-05, Vol.69 (5), p.1292-1306 |
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| creator | Liu, Cong Dai, Shang‐Kun Shi, Ruo‐Xi He, Xuan‐Cheng Wang, Ying‐Ying He, Bao‐Dong Sun, Xiao‐Wen Du, Hong‐Zhen Liu, Chang‐Mei Teng, Zhao‐Qian |
| description | Neurotrauma has been recognized as a risk factor for neurodegenerative diseases, and sex difference of the incidence and outcome of neurodegenerative diseases has long been recognized. Past studies suggest that microglia could play a versatile role in both health and disease. So far, the microglial mechanisms underlying neurodegeneration and potentially lead to sex‐specific therapies are still very open. Here we applied whole transcriptome analysis of microglia acutely isolated at different timepoints after a cortical stab wound injury to gain insight into genes that might be dysregulated and transcriptionally different between males and females after cortical injury. We found that microglia displayed distinct temporal and sexual molecular signatures of transcriptome after cortical injury. Hypotheses and gene candidates that we presented in the present study could be worthy to be examined to explore the roles of microglia in neurotrauma and in sex‐biased neurodegenerative diseases.
Main Points
Microglia display distinct temporal and sexual molecular signatures of transcriptome after cortical injury.
Hypotheses and gene candidates are presented to explore the roles of microglia in neurotrauma and in sex‐biased neurodegenerative diseases. |
| doi_str_mv | 10.1002/glia.23966 |
| format | Article |
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Main Points
Microglia display distinct temporal and sexual molecular signatures of transcriptome after cortical injury.
Hypotheses and gene candidates are presented to explore the roles of microglia in neurotrauma and in sex‐biased neurodegenerative diseases.</description><identifier>ISSN: 0894-1491</identifier><identifier>EISSN: 1098-1136</identifier><identifier>DOI: 10.1002/glia.23966</identifier><identifier>PMID: 33492723</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Brain ; Female ; Gene expression ; Gene Expression Profiling ; Health risks ; Humans ; Injuries ; Life Sciences & Biomedicine ; Male ; Microglia ; microglial ; Neurodegeneration ; Neurodegenerative diseases ; Neurodegenerative Diseases - genetics ; Neurosciences ; Neurosciences & Neurology ; Risk analysis ; Risk factors ; Science & Technology ; Sex ; sex differences ; Transcription ; Transcriptome ; Transcriptomes ; Trauma ; traumatic brain injury</subject><ispartof>Glia, 2021-05, Vol.69 (5), p.1292-1306</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>9</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000611232000001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3576-78d2b1a453fe3e8956c16c98b88344ecec73e332b92dbc5ff057c39a90cd7f23</citedby><cites>FETCH-LOGICAL-c3576-78d2b1a453fe3e8956c16c98b88344ecec73e332b92dbc5ff057c39a90cd7f23</cites><orcidid>0000-0002-7232-3381 ; 0009-0004-2153-2927</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fglia.23966$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fglia.23966$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,39265,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33492723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Cong</creatorcontrib><creatorcontrib>Dai, Shang‐Kun</creatorcontrib><creatorcontrib>Shi, Ruo‐Xi</creatorcontrib><creatorcontrib>He, Xuan‐Cheng</creatorcontrib><creatorcontrib>Wang, Ying‐Ying</creatorcontrib><creatorcontrib>He, Bao‐Dong</creatorcontrib><creatorcontrib>Sun, Xiao‐Wen</creatorcontrib><creatorcontrib>Du, Hong‐Zhen</creatorcontrib><creatorcontrib>Liu, Chang‐Mei</creatorcontrib><creatorcontrib>Teng, Zhao‐Qian</creatorcontrib><title>Transcriptional profiling of microglia in the injured brain reveals distinct molecular features underlying neurodegeneration</title><title>Glia</title><addtitle>GLIA</addtitle><addtitle>Glia</addtitle><description>Neurotrauma has been recognized as a risk factor for neurodegenerative diseases, and sex difference of the incidence and outcome of neurodegenerative diseases has long been recognized. Past studies suggest that microglia could play a versatile role in both health and disease. So far, the microglial mechanisms underlying neurodegeneration and potentially lead to sex‐specific therapies are still very open. Here we applied whole transcriptome analysis of microglia acutely isolated at different timepoints after a cortical stab wound injury to gain insight into genes that might be dysregulated and transcriptionally different between males and females after cortical injury. We found that microglia displayed distinct temporal and sexual molecular signatures of transcriptome after cortical injury. Hypotheses and gene candidates that we presented in the present study could be worthy to be examined to explore the roles of microglia in neurotrauma and in sex‐biased neurodegenerative diseases.
Main Points
Microglia display distinct temporal and sexual molecular signatures of transcriptome after cortical injury.
Hypotheses and gene candidates are presented to explore the roles of microglia in neurotrauma and in sex‐biased neurodegenerative diseases.</description><subject>Brain</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Health risks</subject><subject>Humans</subject><subject>Injuries</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Microglia</subject><subject>microglial</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Neurodegenerative Diseases - genetics</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Science & Technology</subject><subject>Sex</subject><subject>sex differences</subject><subject>Transcription</subject><subject>Transcriptome</subject><subject>Transcriptomes</subject><subject>Trauma</subject><subject>traumatic brain injury</subject><issn>0894-1491</issn><issn>1098-1136</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS1ERZfChQ-ALHFBoLT-lzg-VisolVbqZe-R44wXrxx7sRPQSnx4nO7SAwdUX0a2fu_N-A1C7yi5poSwm513-ppx1TQv0IoS1VaU8uYlWpFWiYoKRS_R65z3hNByka_QJedCMcn4Cv3eJh2ySe4wuRi0x4cUrfMu7HC0eHQmxcUeu4Cn71DKfk4w4D7p8pLgJ2if8eDy5IKZ8Bg9mNnrhC3oqZAZz2GA5I-LYYA5xQF2ECDppd0bdGGLHt6e6xXafv2yXX-rNg939-vbTWV4LZtKtgPrqRY1t8ChVXVjaGNU27ctFwIMGMmBc9YrNvSmtpbU0nClFTGDtIxfoY8n2_K3HzPkqRtdNuC9DhDn3DHRElkLVYuCfvgH3cc5lVwWSknecCFVoT6dqJJOzglsd0hu1OnYUdItK-mWzLrHlRT4_dly7kcYntC_OyhAewJ-QR9tNg6CgSeMENJQyjgjy6FrNz1Gt45zmIr08_OlhaZn2nk4_mfm7m5zf3ua_g99ornv</recordid><startdate>202105</startdate><enddate>202105</enddate><creator>Liu, Cong</creator><creator>Dai, Shang‐Kun</creator><creator>Shi, Ruo‐Xi</creator><creator>He, Xuan‐Cheng</creator><creator>Wang, Ying‐Ying</creator><creator>He, Bao‐Dong</creator><creator>Sun, Xiao‐Wen</creator><creator>Du, Hong‐Zhen</creator><creator>Liu, Chang‐Mei</creator><creator>Teng, Zhao‐Qian</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7232-3381</orcidid><orcidid>https://orcid.org/0009-0004-2153-2927</orcidid></search><sort><creationdate>202105</creationdate><title>Transcriptional profiling of microglia in the injured brain reveals distinct molecular features underlying neurodegeneration</title><author>Liu, Cong ; Dai, Shang‐Kun ; Shi, Ruo‐Xi ; He, Xuan‐Cheng ; Wang, Ying‐Ying ; He, Bao‐Dong ; Sun, Xiao‐Wen ; Du, Hong‐Zhen ; Liu, Chang‐Mei ; Teng, Zhao‐Qian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3576-78d2b1a453fe3e8956c16c98b88344ecec73e332b92dbc5ff057c39a90cd7f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Brain</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Health risks</topic><topic>Humans</topic><topic>Injuries</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Microglia</topic><topic>microglial</topic><topic>Neurodegeneration</topic><topic>Neurodegenerative diseases</topic><topic>Neurodegenerative Diseases - genetics</topic><topic>Neurosciences</topic><topic>Neurosciences & Neurology</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Science & Technology</topic><topic>Sex</topic><topic>sex differences</topic><topic>Transcription</topic><topic>Transcriptome</topic><topic>Transcriptomes</topic><topic>Trauma</topic><topic>traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Cong</creatorcontrib><creatorcontrib>Dai, Shang‐Kun</creatorcontrib><creatorcontrib>Shi, Ruo‐Xi</creatorcontrib><creatorcontrib>He, Xuan‐Cheng</creatorcontrib><creatorcontrib>Wang, Ying‐Ying</creatorcontrib><creatorcontrib>He, Bao‐Dong</creatorcontrib><creatorcontrib>Sun, Xiao‐Wen</creatorcontrib><creatorcontrib>Du, Hong‐Zhen</creatorcontrib><creatorcontrib>Liu, Chang‐Mei</creatorcontrib><creatorcontrib>Teng, Zhao‐Qian</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Glia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Cong</au><au>Dai, Shang‐Kun</au><au>Shi, Ruo‐Xi</au><au>He, Xuan‐Cheng</au><au>Wang, Ying‐Ying</au><au>He, Bao‐Dong</au><au>Sun, Xiao‐Wen</au><au>Du, Hong‐Zhen</au><au>Liu, Chang‐Mei</au><au>Teng, Zhao‐Qian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcriptional profiling of microglia in the injured brain reveals distinct molecular features underlying neurodegeneration</atitle><jtitle>Glia</jtitle><stitle>GLIA</stitle><addtitle>Glia</addtitle><date>2021-05</date><risdate>2021</risdate><volume>69</volume><issue>5</issue><spage>1292</spage><epage>1306</epage><pages>1292-1306</pages><issn>0894-1491</issn><eissn>1098-1136</eissn><abstract>Neurotrauma has been recognized as a risk factor for neurodegenerative diseases, and sex difference of the incidence and outcome of neurodegenerative diseases has long been recognized. Past studies suggest that microglia could play a versatile role in both health and disease. So far, the microglial mechanisms underlying neurodegeneration and potentially lead to sex‐specific therapies are still very open. Here we applied whole transcriptome analysis of microglia acutely isolated at different timepoints after a cortical stab wound injury to gain insight into genes that might be dysregulated and transcriptionally different between males and females after cortical injury. We found that microglia displayed distinct temporal and sexual molecular signatures of transcriptome after cortical injury. Hypotheses and gene candidates that we presented in the present study could be worthy to be examined to explore the roles of microglia in neurotrauma and in sex‐biased neurodegenerative diseases.
Main Points
Microglia display distinct temporal and sexual molecular signatures of transcriptome after cortical injury.
Hypotheses and gene candidates are presented to explore the roles of microglia in neurotrauma and in sex‐biased neurodegenerative diseases.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33492723</pmid><doi>10.1002/glia.23966</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-7232-3381</orcidid><orcidid>https://orcid.org/0009-0004-2153-2927</orcidid></addata></record> |
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| subjects | Brain Female Gene expression Gene Expression Profiling Health risks Humans Injuries Life Sciences & Biomedicine Male Microglia microglial Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - genetics Neurosciences Neurosciences & Neurology Risk analysis Risk factors Science & Technology Sex sex differences Transcription Transcriptome Transcriptomes Trauma traumatic brain injury |
| title | Transcriptional profiling of microglia in the injured brain reveals distinct molecular features underlying neurodegeneration |
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