A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis

Patients hospitalized with decompensated cirrhosis and a serum albumin level of less than 30 g per liter were randomly assigned to daily albumin infusions to raise the albumin level to 30 g per liter or higher or to standard care. Albumin infusions did not reduce the incidences of infection, kidney...

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Veröffentlicht in:	The New England journal of medicine 2021-03, Vol.384 (9), p.808-817
Hauptverfasser:	China, Louise, Freemantle, Nick, Forrest, Ewan, Kallis, Yiannis, Ryder, Stephen D, Wright, Gavin, Portal, Andrew J, Becares Salles, Natalia, Gilroy, Derek W, O’Brien, Alastair
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adverse events Albumin Albumins - administration & dosage Albumins - adverse effects Albumins - therapeutic use Ascites Ascites - etiology Ascites - therapy Cirrhosis Clinical trials Death Feasibility studies Female Hospitalization Humans Inflammation Infusions, Intravenous Kidney diseases Liver cirrhosis Liver Cirrhosis - blood Liver Cirrhosis - complications Liver Cirrhosis - mortality Liver Cirrhosis - therapy Liver Cirrhosis, Alcoholic - blood Liver Cirrhosis, Alcoholic - therapy Liver diseases Male Middle Aged Nosocomial infections Patients Peritonitis Pulmonary Edema - etiology Recruitment Serum Albumin Treatment Failure
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Beschreibung
Zusammenfassung:	Patients hospitalized with decompensated cirrhosis and a serum albumin level of less than 30 g per liter were randomly assigned to daily albumin infusions to raise the albumin level to 30 g per liter or higher or to standard care. Albumin infusions did not reduce the incidences of infection, kidney dysfunction, and death. More serious adverse events occurred in the albumin group.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2022166