Effects of Solanum undatum extract (SR‐T100) on photocarcinogenesis and photoaging of actinic keratosis

SR‐T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B‐induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR‐T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16‐week SR‐T100 gel treatment were documented. SR‐T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR‐T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR‐T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR‐T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.