Magnesium Corrosion Triggered Spontaneous Generation of H2O2 on Oxidized Titanium for Promoting Angiogenesis

Although the use of reactive oxygen species (ROS) has been extensively studied, current systems employ external stimuli such as light or electrical energy to produce ROS, which limits their practical usage. In this report, biocompatible metals were used to construct a novel electrochemical system that can spontaneously generate H2O2 without any external light or voltage. The corrosion of Mg transfers electrons to Au‐decorated oxidized Ti in an energetically favorable process, and the spontaneous generation of H2O2 in an oxygen reduction reaction was revealed to occur at titanium by combined spectroscopic and electrochemical analyses. The controlled release of H2O2 noticeably enhanced in vitro angiogenesis even in the absence of growth factors. Finally, a new titanium implant prototype was developed by Mg incorporation, and its potential for promoting angiogenesis was demonstrated. Nützliche Korrosion: Ein elektrochemisches System, das aus einem biologisch abbaubaren Metall (Mg) und einem Katalysator der Sauerstoffreduktionsreaktion besteht, erzeugt spontan H2O2. Die kontrollierte Freisetzung von H2O2 fördert die Angiogenese in vitro ohne Zugabe von Wachstumsfaktoren. Auch ein gewöhnliches, mit Magnesium funktionalisiertes Titan‐Implantat unterstützt so die Angiogenese.