Maghemite nanoparticles coated by methacrylamide-based polymer for magnetic particle imaging
A wise selection of tracers is critical for magnetic particle imaging (MPI). Most of the current tracers are based on superparamagnetic iron oxide nanoparticles (SPIONs) with a suitable coating. We prepared maghemite cores (γ-Fe 2 O 3 ) by coprecipitation of Fe(II) and Fe(III) salts with ammonium hy...
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Veröffentlicht in: | Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2021-02, Vol.23 (2), Article 52 |
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Sprache: | eng |
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Zusammenfassung: | A wise selection of tracers is critical for magnetic particle imaging (MPI). Most of the current tracers are based on superparamagnetic iron oxide nanoparticles (SPIONs) with a suitable coating. We prepared maghemite cores (γ-Fe
2
O
3
) by coprecipitation of Fe(II) and Fe(III) salts with ammonium hydroxide followed by oxidation with hydrogen peroxide and stabilization as an anionic (γ-Fe
2
O
3
⊖
) or cationic colloid (γ-Fe
2
O
3
⨁
). The cores were coated by poly(
N
-(2-hydroxypropyl)methacrylamide)-co-
N
-[2-(hydroxyamino)-2-oxo-ethyl]-2-methyl-prop-2-enamide. The particles were characterized by dynamic light scattering, transmission electron microscopy, X-ray diffraction, Mössbauer spectroscopy, tested in vitro in a field-free point MPI scanner, and compared to nanoparticles prepared by oxidation with sodium hypochlorite and to the commercially available Resovist®. The cores had an average diameter of 8.0 nm (γ-Fe
2
O
3
⨁
) and 8.7 nm (γ-Fe
2
O
3
⊖
); the hydrodynamic diameter was 88 nm. Zeta potential values for both positively charged (+52 mV) and negatively charged particles (–60 mV) provided for good colloidal stabilization. Spinel structure of maghemite was confirmed by Mössbauer spectroscopy. The uncoated γ-Fe
2
O
3
⨁
particles yielded an MPI signal lower (by 16 %) than Resovist; the coated ones reached 88 % of the Resovist signal. Anionic γ-Fe
2
O
3
⊖
particles reached a higher (uncoated particles, by 15 %) or comparable (coated ones) signal relative to Resovist with a substantially lower signal dispersion. Control particles prepared by oxidation with sodium hypochlorite scored the weakest results. To conclude, a suitable size, narrow size distribution, and colloidal stability predispose the synthetized particles for use as a tracer for MPI. The anionic particles provided a higher signal with a lower dispersion than commercial tracers. |
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ISSN: | 1388-0764 1572-896X |
DOI: | 10.1007/s11051-021-05164-x |