DNA Nanomachines for Identifying Cancer Biomarkers in Body Fluids and Cells

Identifying molecular biomarkers promises to significantly improve the accuracy in cancer diagnosis at its early stage. DNA nanomachines, which are designable and switchable nanostructures made of DNA, show broad potential to detect tumor biomarkers with noninvasive, inexpensive, highly sensitive, a...

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Veröffentlicht in:	Analytical chemistry (Washington) 2021-02, Vol.93 (4), p.1855-1865
Hauptverfasser:	Dong, Zaizai, Xue, Xinying, Liang, Hailun, Guan, Jingjiao, Chang, Lingqian
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Biomarkers Biomarkers, Tumor - chemistry Biosensing Techniques - instrumentation Biosensing Techniques - methods Body fluids Chemistry Deoxyribonucleic acid DNA DNA - chemistry Humans Nanotechnology - instrumentation Nanotechnology - methods Neoplasms - diagnosis
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Beschreibung
Zusammenfassung:	Identifying molecular biomarkers promises to significantly improve the accuracy in cancer diagnosis at its early stage. DNA nanomachines, which are designable and switchable nanostructures made of DNA, show broad potential to detect tumor biomarkers with noninvasive, inexpensive, highly sensitive, and highly specific advantages. This Feature summarizes the recent DNA nanomachine-based platforms for the early detection of cancer biomarkers, both from body fluids and in cells.
ISSN:	0003-2700 1520-6882
DOI:	10.1021/acs.analchem.0c03518