Evaluation of maternal serum afamin and vitamin E levels in pregnant women with COVID‐19 and its association with composite adverse perinatal outcomes
To evaluate the maternal serum afamin and vitamin E levels in pregnant women with coronavirus disease 2019 (COVID‐19) and to investigate their association with composite adverse perinatal outcomes. This prospective, case‐control study consisted of 60 pregnant women with COVID‐19 infection and 36 age...
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| Veröffentlicht in: | Journal of medical virology 2021-04, Vol.93 (4), p.2350-2358 |
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| creator | Erol, Seyit A. Tanacan, Atakan Anuk, Ali T. Tokalioglu, Eda O. Biriken, Derya Keskin, Huseyin L. Moraloglu, Ozlem T. Yazihan, Nuray Sahin, Dilek |
| description | To evaluate the maternal serum afamin and vitamin E levels in pregnant women with coronavirus disease 2019 (COVID‐19) and to investigate their association with composite adverse perinatal outcomes. This prospective, case‐control study consisted of 60 pregnant women with COVID‐19 infection and 36 age‐matched pregnant women without any defined risk factors. Demographic features, laboratory test results, afamin and vitamin E levels were compared between the groups. A receiver operating characteristic (ROC) curve was used to assess the relationship of afamin and vitamin E levels in predicting composite adverse perinatal outcomes. A correlation analysis was performed between afamin and C‐reactive protein (CRP) levels in pregnant women with COVID‐19. The obstetric complication rate was higher in the COVID‐19 group (13.3% vs. 2.8%) (p = .01). Afamin levels were higher and vitamin E levels were lower in the COVID‐19 group (p = .02 and p |
| doi_str_mv | 10.1002/jmv.26725 |
| format | Article |
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This prospective, case‐control study consisted of 60 pregnant women with COVID‐19 infection and 36 age‐matched pregnant women without any defined risk factors. Demographic features, laboratory test results, afamin and vitamin E levels were compared between the groups. A receiver operating characteristic (ROC) curve was used to assess the relationship of afamin and vitamin E levels in predicting composite adverse perinatal outcomes. A correlation analysis was performed between afamin and C‐reactive protein (CRP) levels in pregnant women with COVID‐19. The obstetric complication rate was higher in the COVID‐19 group (13.3% vs. 2.8%) (p = .01). Afamin levels were higher and vitamin E levels were lower in the COVID‐19 group (p = .02 and p < .001, respectively). Vitamin E levels were lower in the COVID‐19 group for the all trimesters (p < .001, p < .001, and p = .004, respectively). Afamin levels were higher in the COVID‐19 group for the all trimesters without reaching statistical significance (p > .05). The values in the ROC curves with the best balance of sensitivity/specificity for afamin and vitamin E were 0.424 mg/l (70.6% sensitivity, 44.3% specificity) and 3.150 µg/ml (76.5% sensitivity, 58.2% specificity), respectively. A positive moderate statistically significant correlation was found between afamin and CRP levels (r = .264, p = .009). Higher afamin and lower vitamin E levels may support the elevated oxidative stress in the etiopathogenesis of COVID‐19 and the relationship with composite adverse perinatal outcomes.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.26725</identifier><identifier>PMID: 33314206</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; adverse outcome ; afamin ; C-Reactive Protein - metabolism ; Carrier Proteins - blood ; Case-Control Studies ; Coronaviruses ; Correlation analysis ; COVID-19 ; COVID-19 - blood ; COVID-19 - epidemiology ; COVID-19 - virology ; Evaluation ; Female ; Glycoproteins - blood ; Humans ; Laboratory tests ; Oxidative stress ; Oxidative Stress - physiology ; Pregnancy ; Pregnancy Complications, Infectious - blood ; Pregnancy Complications, Infectious - virology ; Pregnancy Outcome ; Prospective Studies ; Risk analysis ; Risk factors ; SARS‐CoV‐2 ; Sensitivity ; Sensitivity and Specificity ; Serum Albumin, Human - metabolism ; Statistical analysis ; Tocopherol ; Turkey - epidemiology ; Viral diseases ; Virology ; Vitamin E ; Vitamin E - blood</subject><ispartof>Journal of medical virology, 2021-04, Vol.93 (4), p.2350-2358</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><rights>2021 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4165-33bfac19dae7e9d5da4db58cd56977f3e248e360e7e9ad468916f210a6babd0f3</citedby><cites>FETCH-LOGICAL-c4165-33bfac19dae7e9d5da4db58cd56977f3e248e360e7e9ad468916f210a6babd0f3</cites><orcidid>0000-0001-8567-9048 ; 0000-0002-2268-3821 ; 0000-0003-1237-8468 ; 0000-0001-8209-8248 ; 0000-0002-6254-4578 ; 0000-0001-8167-3837 ; 0000-0002-2494-4896 ; 0000-0001-5437-1008 ; 0000-0003-4901-0544</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.26725$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.26725$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33314206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erol, Seyit A.</creatorcontrib><creatorcontrib>Tanacan, Atakan</creatorcontrib><creatorcontrib>Anuk, Ali T.</creatorcontrib><creatorcontrib>Tokalioglu, Eda O.</creatorcontrib><creatorcontrib>Biriken, Derya</creatorcontrib><creatorcontrib>Keskin, Huseyin L.</creatorcontrib><creatorcontrib>Moraloglu, Ozlem T.</creatorcontrib><creatorcontrib>Yazihan, Nuray</creatorcontrib><creatorcontrib>Sahin, Dilek</creatorcontrib><title>Evaluation of maternal serum afamin and vitamin E levels in pregnant women with COVID‐19 and its association with composite adverse perinatal outcomes</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>To evaluate the maternal serum afamin and vitamin E levels in pregnant women with coronavirus disease 2019 (COVID‐19) and to investigate their association with composite adverse perinatal outcomes. This prospective, case‐control study consisted of 60 pregnant women with COVID‐19 infection and 36 age‐matched pregnant women without any defined risk factors. Demographic features, laboratory test results, afamin and vitamin E levels were compared between the groups. A receiver operating characteristic (ROC) curve was used to assess the relationship of afamin and vitamin E levels in predicting composite adverse perinatal outcomes. A correlation analysis was performed between afamin and C‐reactive protein (CRP) levels in pregnant women with COVID‐19. The obstetric complication rate was higher in the COVID‐19 group (13.3% vs. 2.8%) (p = .01). Afamin levels were higher and vitamin E levels were lower in the COVID‐19 group (p = .02 and p < .001, respectively). Vitamin E levels were lower in the COVID‐19 group for the all trimesters (p < .001, p < .001, and p = .004, respectively). Afamin levels were higher in the COVID‐19 group for the all trimesters without reaching statistical significance (p > .05). The values in the ROC curves with the best balance of sensitivity/specificity for afamin and vitamin E were 0.424 mg/l (70.6% sensitivity, 44.3% specificity) and 3.150 µg/ml (76.5% sensitivity, 58.2% specificity), respectively. A positive moderate statistically significant correlation was found between afamin and CRP levels (r = .264, p = .009). Higher afamin and lower vitamin E levels may support the elevated oxidative stress in the etiopathogenesis of COVID‐19 and the relationship with composite adverse perinatal outcomes.</description><subject>Adult</subject><subject>adverse outcome</subject><subject>afamin</subject><subject>C-Reactive Protein - metabolism</subject><subject>Carrier Proteins - blood</subject><subject>Case-Control Studies</subject><subject>Coronaviruses</subject><subject>Correlation analysis</subject><subject>COVID-19</subject><subject>COVID-19 - blood</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - virology</subject><subject>Evaluation</subject><subject>Female</subject><subject>Glycoproteins - blood</subject><subject>Humans</subject><subject>Laboratory tests</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - blood</subject><subject>Pregnancy Complications, Infectious - virology</subject><subject>Pregnancy Outcome</subject><subject>Prospective Studies</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>SARS‐CoV‐2</subject><subject>Sensitivity</subject><subject>Sensitivity and Specificity</subject><subject>Serum Albumin, Human - metabolism</subject><subject>Statistical analysis</subject><subject>Tocopherol</subject><subject>Turkey - epidemiology</subject><subject>Viral diseases</subject><subject>Virology</subject><subject>Vitamin E</subject><subject>Vitamin E - blood</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhi0EotvCgRdAlrjQQ1rbcZz1EW0XKCrqBXqNJvEEvEriYDtZ9cYjcOT5eBK8m8IBidOM9H_z_9L8hLzg7IIzJi53_XwhVCmKR2TFmVaZZiV_TFaMS5UpxYsTchrCjjG21kI8JSd5nnMpmFqRn9sZugmidQN1Le0hoh-gowH91FNoobcDhcHQ2cbjvqUdztgFmvbR45cBhkj3rseB7m38Sje3d9dXv77_4Pp4ZmOgEIJr7JJxZBrXjy7YiBTMjD4gHdHbAWIKdlNMMoZn5EkLXcDnD_OMfH67_bR5n93cvrvevLnJGslVkeV53ULDtQEsUZvCgDR1sW5MoXRZtjkKucZcsYMKRqq15qoVnIGqoTaszc_I68V39O7bhCFWvQ0Ndh0M6KZQCVmmF0tZ8IS--gfduenwrQOlGReK6zJR5wvVeBeCx7Yave3B31ecVYe6qlRXdawrsS8fHKe6R_OX_NNPAi4XYG87vP-_U_Xh491i-RvL26Ic</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Erol, Seyit A.</creator><creator>Tanacan, Atakan</creator><creator>Anuk, Ali T.</creator><creator>Tokalioglu, Eda O.</creator><creator>Biriken, Derya</creator><creator>Keskin, Huseyin L.</creator><creator>Moraloglu, Ozlem T.</creator><creator>Yazihan, Nuray</creator><creator>Sahin, Dilek</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8567-9048</orcidid><orcidid>https://orcid.org/0000-0002-2268-3821</orcidid><orcidid>https://orcid.org/0000-0003-1237-8468</orcidid><orcidid>https://orcid.org/0000-0001-8209-8248</orcidid><orcidid>https://orcid.org/0000-0002-6254-4578</orcidid><orcidid>https://orcid.org/0000-0001-8167-3837</orcidid><orcidid>https://orcid.org/0000-0002-2494-4896</orcidid><orcidid>https://orcid.org/0000-0001-5437-1008</orcidid><orcidid>https://orcid.org/0000-0003-4901-0544</orcidid></search><sort><creationdate>202104</creationdate><title>Evaluation of maternal serum afamin and vitamin E levels in pregnant women with COVID‐19 and its association with composite adverse perinatal outcomes</title><author>Erol, Seyit A. ; Tanacan, Atakan ; Anuk, Ali T. ; Tokalioglu, Eda O. ; Biriken, Derya ; Keskin, Huseyin L. ; Moraloglu, Ozlem T. ; Yazihan, Nuray ; Sahin, Dilek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4165-33bfac19dae7e9d5da4db58cd56977f3e248e360e7e9ad468916f210a6babd0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>adverse outcome</topic><topic>afamin</topic><topic>C-Reactive Protein - metabolism</topic><topic>Carrier Proteins - blood</topic><topic>Case-Control Studies</topic><topic>Coronaviruses</topic><topic>Correlation analysis</topic><topic>COVID-19</topic><topic>COVID-19 - blood</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 - virology</topic><topic>Evaluation</topic><topic>Female</topic><topic>Glycoproteins - blood</topic><topic>Humans</topic><topic>Laboratory tests</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - blood</topic><topic>Pregnancy Complications, Infectious - virology</topic><topic>Pregnancy Outcome</topic><topic>Prospective Studies</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>SARS‐CoV‐2</topic><topic>Sensitivity</topic><topic>Sensitivity and Specificity</topic><topic>Serum Albumin, Human - metabolism</topic><topic>Statistical analysis</topic><topic>Tocopherol</topic><topic>Turkey - epidemiology</topic><topic>Viral diseases</topic><topic>Virology</topic><topic>Vitamin E</topic><topic>Vitamin E - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erol, Seyit A.</creatorcontrib><creatorcontrib>Tanacan, Atakan</creatorcontrib><creatorcontrib>Anuk, Ali T.</creatorcontrib><creatorcontrib>Tokalioglu, Eda O.</creatorcontrib><creatorcontrib>Biriken, Derya</creatorcontrib><creatorcontrib>Keskin, Huseyin L.</creatorcontrib><creatorcontrib>Moraloglu, Ozlem T.</creatorcontrib><creatorcontrib>Yazihan, Nuray</creatorcontrib><creatorcontrib>Sahin, Dilek</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erol, Seyit A.</au><au>Tanacan, Atakan</au><au>Anuk, Ali T.</au><au>Tokalioglu, Eda O.</au><au>Biriken, Derya</au><au>Keskin, Huseyin L.</au><au>Moraloglu, Ozlem T.</au><au>Yazihan, Nuray</au><au>Sahin, Dilek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of maternal serum afamin and vitamin E levels in pregnant women with COVID‐19 and its association with composite adverse perinatal outcomes</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J Med Virol</addtitle><date>2021-04</date><risdate>2021</risdate><volume>93</volume><issue>4</issue><spage>2350</spage><epage>2358</epage><pages>2350-2358</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>To evaluate the maternal serum afamin and vitamin E levels in pregnant women with coronavirus disease 2019 (COVID‐19) and to investigate their association with composite adverse perinatal outcomes. This prospective, case‐control study consisted of 60 pregnant women with COVID‐19 infection and 36 age‐matched pregnant women without any defined risk factors. Demographic features, laboratory test results, afamin and vitamin E levels were compared between the groups. A receiver operating characteristic (ROC) curve was used to assess the relationship of afamin and vitamin E levels in predicting composite adverse perinatal outcomes. A correlation analysis was performed between afamin and C‐reactive protein (CRP) levels in pregnant women with COVID‐19. The obstetric complication rate was higher in the COVID‐19 group (13.3% vs. 2.8%) (p = .01). Afamin levels were higher and vitamin E levels were lower in the COVID‐19 group (p = .02 and p < .001, respectively). Vitamin E levels were lower in the COVID‐19 group for the all trimesters (p < .001, p < .001, and p = .004, respectively). Afamin levels were higher in the COVID‐19 group for the all trimesters without reaching statistical significance (p > .05). The values in the ROC curves with the best balance of sensitivity/specificity for afamin and vitamin E were 0.424 mg/l (70.6% sensitivity, 44.3% specificity) and 3.150 µg/ml (76.5% sensitivity, 58.2% specificity), respectively. A positive moderate statistically significant correlation was found between afamin and CRP levels (r = .264, p = .009). Higher afamin and lower vitamin E levels may support the elevated oxidative stress in the etiopathogenesis of COVID‐19 and the relationship with composite adverse perinatal outcomes.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33314206</pmid><doi>10.1002/jmv.26725</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8567-9048</orcidid><orcidid>https://orcid.org/0000-0002-2268-3821</orcidid><orcidid>https://orcid.org/0000-0003-1237-8468</orcidid><orcidid>https://orcid.org/0000-0001-8209-8248</orcidid><orcidid>https://orcid.org/0000-0002-6254-4578</orcidid><orcidid>https://orcid.org/0000-0001-8167-3837</orcidid><orcidid>https://orcid.org/0000-0002-2494-4896</orcidid><orcidid>https://orcid.org/0000-0001-5437-1008</orcidid><orcidid>https://orcid.org/0000-0003-4901-0544</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult adverse outcome afamin C-Reactive Protein - metabolism Carrier Proteins - blood Case-Control Studies Coronaviruses Correlation analysis COVID-19 COVID-19 - blood COVID-19 - epidemiology COVID-19 - virology Evaluation Female Glycoproteins - blood Humans Laboratory tests Oxidative stress Oxidative Stress - physiology Pregnancy Pregnancy Complications, Infectious - blood Pregnancy Complications, Infectious - virology Pregnancy Outcome Prospective Studies Risk analysis Risk factors SARS‐CoV‐2 Sensitivity Sensitivity and Specificity Serum Albumin, Human - metabolism Statistical analysis Tocopherol Turkey - epidemiology Viral diseases Virology Vitamin E Vitamin E - blood |
| title | Evaluation of maternal serum afamin and vitamin E levels in pregnant women with COVID‐19 and its association with composite adverse perinatal outcomes |
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