Evaluation of maternal serum afamin and vitamin E levels in pregnant women with COVID‐19 and its association with composite adverse perinatal outcomes

To evaluate the maternal serum afamin and vitamin E levels in pregnant women with coronavirus disease 2019 (COVID‐19) and to investigate their association with composite adverse perinatal outcomes. This prospective, case‐control study consisted of 60 pregnant women with COVID‐19 infection and 36 age‐matched pregnant women without any defined risk factors. Demographic features, laboratory test results, afamin and vitamin E levels were compared between the groups. A receiver operating characteristic (ROC) curve was used to assess the relationship of afamin and vitamin E levels in predicting composite adverse perinatal outcomes. A correlation analysis was performed between afamin and C‐reactive protein (CRP) levels in pregnant women with COVID‐19. The obstetric complication rate was higher in the COVID‐19 group (13.3% vs. 2.8%) (p = .01). Afamin levels were higher and vitamin E levels were lower in the COVID‐19 group (p = .02 and p