A novel norneolignan glycoside and four new phenolic glycosides from the stems of Viburnum fordiae Hance

A novel norneolignan glycoside ( ), categorized as an unusual 7-noraryl-4′,7-epoxy-8,5′-neolignan glycoside, four new phenolic glycosides ( ), and a known neolignan glycoside ( ) have been isolated from the ethanolic extract of the stems of Hance. Dried stems of were extracted with 95% ethanol, and the concentrated extract was portioned successively with petroleum ether, ethyl acetate and -butanol. The -butanol portion was subjected to the macroporous resin HPD-100, silica gel, octadecyl SiO , MCI gel and Sephadex LH-20 columns to obtain six compounds. Their structures including absolute configurations were determined by spectroscopic data [ H and C nuclear magnetic resonance (NMR), total correlation spectroscopy (TOCSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple-bond correlation (HMBC) and optical rotatory dispersion (ORD)] and chemical methods.